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Science Based Skincare
As we age, our skin loses its firmness, toxins accumulate, and cell production declines. Moreover, the penetration of harmful, longer UV rays is multifold, attributed to the greenhouse effect, leading to multiple skin disorders. The pollution and harsher climatic conditions trigger the already going process of aging. This phenomenon has transformed the definition of skin care from cosmetic brand supremacy to a research-oriented and medically ascertained science.
Led by a Team of Scientists and Doctors
With this aspiration, SKINCOMM® stepped into the field to target hyperpigmentation, sagginess, dehydration, blemishes and open pores to provide healthy, flawless, glowing, bright skin not only apparently, but by tackling the underlying issues through a result-oriented skincare regime. It was made possible by bringing together scientists, medical health professionals, and skin care experts under one umbrella of this Singaporean skincare brand of SKINCOMM®. The purpose is to understand the phenomenon behind skin problems and drive a sustainable solution.
Advocation
The brand is a hardcore advocate of clean beauty and assures that the products are free from all prohibited and unhealthy ingredients, including parabens and fragrances, to provide skincare with safety protocols upheld. Plus, the products are HSA compliant, animal cruelty-free, and adhere to GMP standards of safety, consistency, and quality.
Concept of Cell Energizer
- Research works on damage and aging (Cell Senescence)
- Cell senescence is the termination of the normal cell cycle attributed to any external or internal stimulus or developmental indicators. The process triggers aging by sabotaging tissue regeneration causing loss of a cell’s power of division and growth.
- Scientifically, aging is the cellular senescence upsurge, leading the cells to an unrepairable and unreproducible state where they fail to maintain healthy cell homeostasis. Cellular senescence is apparent in gray hair, wrinkles, memory loss, immunity reduction, and bone degeneration.
- Contrary to this is the concept of active aging. According to WHO, active aging is optimizing the aging process to minimize physical and mental degeneration. This concept can help facilitate aging with minimal degenerative effects.
- The aim of SKINCOMM® is the same to minimize the apparent signs of skin aging through its product. To manage or reverse aging, we are employing anti-aging medication that revives the regenerative and restoring cell properties.
- The cause of aging cell
The linear chromosomal ends are called telomeres, the protecting structures that help prevent genome manipulations. In all DNA-based organisms, telomeres are vital in cell division. As we age, telomeres shorten, ascribed to cell divisions. Sometimes due to excessive division, telomeres shorten enough to trigger a phenomenon of cell dysfunctionality or senescence. These senescent cells accumulate in the tissues of mammals as they age. They are responsible for multiple age-associated ailments attributed to tissue deterioration. On the other hand, longer telomeres equate to a healthy and longer life with younger biological age. A person of 60 years could be biologically younger because of longer telomeres protecting their cells. So telomeres attrition or shortening is the marker of aging.
Aging goes on, and all the cells eventually die except for stem cells. These cells have a remarkable self-renewal ability and are able to stimulate the enzymes called telomerase to revamp telomeres, which help them retain replication ability and the ability to differentiate in any cell that is required by the body through their property of pluripotency. Other than cell division, telomere attrition results from multiple factors, including replication, oxidative stress, and inflammation.
In a 2011 study, researchers found that telomerase is active in multiple skin cells, specifically in the epidermis (the outer layer of skin), with “increasing evidence” indicating its significant role in maintaining skin functionality and revitalization. Mutations in telomerase genes resulted in several skin anomalies.
The scientists further claimed that telomeres in skin cells are particularly vulnerable to attrition because of their high exposure to DNA-damaging agents such as UV rays and free radicals.
They concluded that increasing telomerase activity and protecting telomere length can help rejuvenate skin. Also, they may help reduce the risk of age-associated skin diseases.
Cell Communicator
Cell communication
All body cells, including skin cells, need to communicate with each other to function smoothly. The communication helps generate a response to an extrinsic stimulus through signal transfer. In humans, cells continuously communicate through chemical signals to regulate the functions of body organs and systems. The high efficiency of cells in sending and receiving signals enables smooth coordination and calibrated operation.
Like all other body parts, skin cells know the key to effective communication, how to and when to perform a specific task, so that it works in synchronization with other cells and generates a cohesive response. This communication is brought about by many chemical substances which guide cells about their specific role according to time and help them synchronize with each other. Different chemical agents are responsible for skin communication. They include growth factors and antioxidants.
Boosting skin cell communication
The cell communication agents deal with skin concerns, the most significant of which is aging. These agents help skin cells prevent signs of aging by aiding them to perform a specific task with efficacy. They may also direct the cell to perform their parent product’s specified task. Enhancing cell communication is a deep skincare regime to resolve underlying skin problems. With aging, the chemicals that generate signals decline in the skin, leaving saggy, wrinkled, and aged skin. However, it is now possible to boost these communicator signal chemicals using appropriate skincare products.
Formulations
SKINCOMM® has made tremendous progress in this incredible skincare horizon and launched products that help enhance cell communication functions. SKINCOMM® has established a complete skincare set of five products, including Cleanser Aqua+, Essence YouthRefiner, Actives YouthVital, Complex YouthLoc and Mask YouthNutri.. The aim is to target multiple skin issues at one go and serve as an all-in-one solution.
The Proprietary Ingredient System
The brand has a vision of bringing research-based and scientifically correct skincare systems through proprietary ingredients. Our experts work tirelessly to bring our original formulations for your skin problems.
AL-GLUTAS®
Mitochondria (the powerhouse of cells) maintains cell vitality by producing energy. The mitochondrial debilitation induces cell senescence and telomere attrition.
AL-GLUTAS® has been specifically formulated to re-program the mitochondria of cells for biosynthesis and functionality. The botanical concentrates of AL-GLUTAS® are endowed by clinical trials in their efficiency against telomeres shortening and skin aging.
- It enhances anaerobic glycolysis and intensifies mitochondrial respiration ushering the increased ATP production.
- In response to a higher UV exposure, it activates the genes that improve anaerobic respiration and enhance mitochondrial defense and revitalization.
- It enhances the body’s energy level daily according to skin needs. It provides an extra dose of energy for the skin to rejuvenate.
- AL-GLUTAS® is an adenosine and amino acid-rich formula. The amino acid augments the healing power of the skin, while adenosine reduces the appearance of wrinkles on the skin.
- It helps expedite the rate of cell surface revival by up to 4 days.
- In case of UV damage, it activates the cutaneous restoration process.
TriDefenx™ System
According to advanced research, not only UVA and UVB but the light emitted from electronic devices, including High Energy Visible Light (HEVL) and Infrared Radiation (IR), also damages the vitality of skin cells.
TriDefenx™ System combines robust and galvanized natural agents that fortify your skin with a full spectrum defense against UVA, UVB, IR-A, HEVL, or Blue Light. These rays, if penetrating the skin, can cause cells to age rapidly and deteriorate the skin cells’ DNA.
Interpretation of the Clinical Trials & Studies Report
Our formulations are backed up by vigorous research and are scientifically tested and proven. The in-Vivo and in-Vitro clinical tests validate the product safety.
- Efficacy Report - Melanin Reduction
SKINCOMM® Actives YouthVital and Mask YouthNutri were tested in a 21-day clinical trial to assess the products by direct application on the epidermal layer of skin. The in-vitro melanin quantification was performed on 3D skin models against four variables as follows:
a) Blank (negative control)
b) Kojic Acid (positive control)
c) Vital
d) Vital+Mask
The models were studied under a microscope after 21 days of pigmentation in respective cultures, and significant lightening was observed in vital and vital+mask samples. The melanin quantification result revealed a 58.63% (p 0.001) overall reduction in melanin content by the combined effect of vital+mask, while a 37.84% (0.01) melanin reduction was observed in Vital only against negative control.
The obtained results proved the efficacy of YouthVitals and YouthNutri for flawless and bright complexioned skin.
● Efficacy Report -Collagen, Elastin
The mechanism of YouthVital action is such that it strengthens collagen and elastin by preventing atrophy. The 3D skin model was treated with 16 uL of SKINCOMM® UNICEL Actives YouthVital for 72 for pro-collagen levels determination against a negative control with no treatments. The pro-collagen was quantified using an Enzyme-linked immunosorbent assay (ELISA) kit, which mainly detects antibodies or proteins in the samples. A standard ELISA curve determines the level of a specified analyte. Serial dilutions against the known concentration of pro-collagen were made to obtain the curve. Relative and independent pro-collagen levels in cell culture were determined.
The results revealed a 54% increase in pro-collagen level compared to the control. The relative pro-collagen level of the test and control was 1.54 and 1, respectively, while the means and standard deviations were (vital: 0.56525 and control: 0.0622). The increase in pro-collagen implied that the product under trial helps keep skin hydrated, supple and dense.
An Elastin ELISA assay was performed by applying 32 uL of Elastin for 72 hours against a negative control. The results indicated a 429% elastin increase after 72 hrs compared to the negative control. The relative elastin content in the test and control were 1 and 4, obtained from graphical data of the ELISA assay. The obtained results indicated the test product’s efficiency in boosting elastin levels.
Lastly, in-house clinical trials on consumers were conducted under strict dermatological protocols. The results of the trials showed visible differences in skin condition pre and post-product, asserting the success of the test product.
Quality and Assurance
Manufactured under GMP Standard
SKINCOMM® formulates products that satisfy the manufacturing practices (GMP) standards. For this purpose, the company corroborates that safety protocols are followed strictly from resourcing the raw material to final product fabrication. The consistency is maintained by controlling all variables to achieve high-quality products, adopting top-notch mechanisms, professional experience, and sterling formulas.
Laboratory In-Vitro Tested
As skin care products come directly in contact with the human body, it is necessary to test them according to established protocols. SKINCOMM® ensures the products are safe, free from cytotoxicity and phototoxicity, and efficient in their mechanism of action by following a series of in vitro testing before launching the products into markets.
Clinical In-Vivo Tested
After the successful in-vitro experimentation, products underwent in-vivo human subjects clinical trials. The results satisfied quality compliance and product efficacy.
Dermatologically Tested
SKINCOMM® ensures the products are safe and suitable for all skin types. All products underwent internationally accepted hypoallergenic testing of topical products, In Vivo Evaluation Irritation Potency Single Patch Test Method Under Dermatological Control. Under these study conditions, the product can be considered non-irritating.
Clean Formulation
The concept of clean formulations is the top priority of the brand. So, it is ensured that the ingredients used are safe, in recommended dosage, and with maximum efficiency. Parabens, phthalates, formaldehyde, and other harmful actors are avoided as the intent is to formulate clean and safe beauty products.
Ethically Sourced Premium AAA Grade Ingredients
The brand maintains its product quality through ethical sourcing and triple A-grade ingredients, which is possible because of research and quality control mechanisms for raw ingredients procurement.
HSA Registered - Made in Singapore product
Our wide assortment of skincare products' ingredients, formulas, and quality parameters follow HSA-conceived standards for products in Singapore.
Not Tested on Animal
The company strictly adheres to the cruelty-free concept, and the product array does not involve testing on animals at any stage, from resourcing to development.
Proprietary Formulations
The revolutionary products of SKINCOMM® have roots in the proprietary formulas codified by its team of experts targeted to resolve skin concerns at the cellular level.
Safety Assessment
The internal regulatory mechanism of the company prioritizes that the formulas, toxicology, chemical nature, and application of products fulfill the safety assessment procedures of health science authorities.
Gone are the days where more is the best… SKINCOMM® All & One multi-functional skincare offers you Efficacy and Efficiency on your skin and your time…
